website development annapolis md

2022.03.26

website development annapolis md


Although medical development is very fast now,But contemporary“Talk about cancer color change”。According to the international cancer research institution:Global2020yearnewly added1930Wancanga patient,andhave100010,000 people die due to cancer


This data is collected185Countryand36Different cancer typesAt present, every five people in the world will have a person who has cancer in his life.。Such numbers are really scary,thereforePeople have never disgraced to cancer's fear


In recent years,Related Medicine、Technicians are also committed toStudy more ways to treat cancer

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website development annapolis md(Website Development Annapolis MD)


A headquartersBioton and Seattle's Biotechnology StartupAffini-T TherapeuticsOne of them is also。

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The company announcedHas been raised1.75Billion dollarsUsed to develop cancerTCell therapy。And this is alsoOne of the biggest releases in the biotechnology field this year


website development annapolis md(Website Development Annapolis MD)


(Website Development Annapolis MD)And these fundraisingBoston venture capital companyVida VenturesandGerman pharmaceutical company's early investment departmentLeaps by Bayer,Two companiesLead together1.75Billion dollar financing


althoughCurrently developed cell therapy(cell therapies)Only approved for treatment of blood cancer,butAffini-TI hope to use it laterCell therapy to treat proteinKRASThose caused diseases in tumors

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website development annapolis md


Speaking of which,There should be a lot of puyors.。

This is briefly introduced here.What kind of proteinKRAS


website development annapolis md(Website Development Annapolis MD)

GIF from: GIPHY


according toBio Valley(Bioon.com)introduce:RASIs one of the most common carcinogenic genes in tumor patients,CurrentlyKRASNRASas well asHRASThree subtypes(subtype)。


whenNRASmutation,OftenMelanomaandAcute bone marrow leukemiaSee;HRASmutationMore commonBladder CancerandHead-necked cancer;andKRASMore common than two subtypes,FrequentlyLung cancerPancreatic cancerandColorectal cancermiddle。


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National Cancer InstituteData representation:haveExceed30%Human cancer,include:95%Pancreatic cancerand45%Colon cancerYesDepend onRASFamily gene mutation drive

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Affini-TJoint founderPresidentConcludeCEOJak KnowlesPhDSay:TheseMutation geneWillingCancer cells grow and split


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In factTumoristKRASNot novel discovery,They have been in these decadesMedicinal designereffortLooking for molecules that can identify mutation proteins。KnowlesSay:Many people realizeIt is the basis of cancer virusesBut it is very difficult to solve


website development annapolis md

GIF from: GIPHY


but,Emperor is not worried。American Food and Drug Administration (Food and Drug Administration)existLast year approved the firstKRASInhibitor,This is a kind ofTreatment of lung cancer,andNamedLumakrasPill


But this drug can only be used to inhibitG12CMutationKRASprotein


website development annapolis md(Website Development Annapolis MD)



therefore,Affini-THow to useTCell therapy to inhibit the nameG12VandG12DMutationKRASprotein。becauseTCell receptor(T-cell receptor)Be able to identifyInfectOrTumor


ThisTwo typesKRASmutationexistPancreatic cancerColon cancerandThat is common in lung cancer。


website development annapolis md



SeattleFred HutchinsonCancer Research CenterofImmunologistPhilip GreenbergPhDexistThe young body found*TargetedKRASMutationTCell receptor


therefore,GreenbergAnd team planningThese homing(homing)Beacon(beacons)Add to byKRAS引起癌症患者Take actionTCancer patients中。


Kowlescell:预计明年开始展开这些项目


*middle:对特定目标(Express、细胞、It is expected that these items began to start next year.)采取行动。

website development annapolis md(Website Development Annapolis MD)


molecularAffini-T正在与cellDyno Therapeutics租用实验室空间,Individual位于Watertown的9层的实验室


website development annapolis md


ViaDevelopment to treat cancerAffini-T联合创始人Arjun GoyalCell therapyLaboratory:Currently,但说到细胞疗法时,Gene therapy company费城Rental laboratory space西海岸。But plan to move to a near future将公司搬到波士顿还是非常正确的决定


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Knowles说:波士顿的人才济济,Boston Biotechnology Company Heavy管理团队非常出色

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